Bring a Small Bag
If you're the kind of person who keeps everything in his/her pockets, this one's for you. Normally, good pockets will help you travel light and avoid carrying a big bag, but planes are a different story.
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Since you'll be sitting down most of the time and given that your carry-on is in the overhead compartment, you probably don't feel like getting up whenever you need your wallet, bubblegum, or the USB key on your keychain. Get a little bag to fit all those items in and stick it in the pocket of the seat in front of you as you buckle up.
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Plan Your Bathroom Breaks
Waiting in line for the aircraft bathroom is no fun. This is why you want to carefully plan your trips to the toilet when you can. It is less likely to have a long line to the bathroom right after takeoff (of course, only after the seatbelt sign is turned off) and before the crew starts rolling out the drink cart.
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Time your visits to the potty palace, and you can do your business in peace. Just know that if you don't leave after 20 minutes, a staff member will have to knock and make sure everything is in order.